Vaginal microbiomes and ovarian cancer: a review

The human microbiome, often termed as "the forgotten organ", is an aggregation of microorganisms and their genomes that forms a mutualistic complex with the host. Recent research has shown the symbiotic merits of a microbiome ecosystem and its crucial role in the hosts' physiological...

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Published inAmerican journal of cancer research Vol. 10; no. 3; pp. 743 - 756
Main Authors Xu, Jinyun, Peng, Jing-Jie, Yang, Wenqing, Fu, Kun, Zhang, Yu
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2020
Subjects
Review
Vaginal microbiome
immune response
ovarian cancer
cervical cancer
HPV
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Summary:The human microbiome, often termed as "the forgotten organ", is an aggregation of microorganisms and their genomes that forms a mutualistic complex with the host. Recent research has shown the symbiotic merits of a microbiome ecosystem and its crucial role in the hosts' physiological functions. Disruption of this symbiotic relationship is prone to cause a broad spectrum of ailments, including cancer. The compositional and environmental factors that tip the scales from beneficial co-existence to the development of malignancy is actively investigated. Herein we review the latest research in knowledge regarding the association between the vaginal microbiomes and oncogenesis, with a particular focus on ovarian carcinoma.
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ISSN:2156-6976
2156-6976