Association of gene polymorphisms with the susceptibility of schizophrenia in Han Chinese population

• Published in: Zhong hua yi xue za zhi Vol. 95; no. 47; p. 3803
• Main Authors: Yu, Hongyan, Zhang, Haisan, Yang, Yongfeng, Li, Wenqiang, Zhang, Hongxing, Yang, Ge, Lü, Luxian
• Format: Journal Article
• Language: Chinese
• Published: China 15.12.2015
• Subjects: Asian Continental Ancestry Group; Carbonic Anhydrase I - genetics; Carrier Proteins - genetics; Case-Control Studies; China; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Membrane Proteins - genetics; Peptide Hydrolases - genetics; Polymorphism, Single Nucleotide; Racemases and Epimerases - genetics; Schizophrenia - genetics; China
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2015.47.002

To investigate the potential association of carbonic anhydrase I (CA1) anterior pharynx-defective 1A ( APH1A), neurodevelopment protein 1-like 1 (NDEL1) and serine racemase (SRR) gene polymorphisms with the susceptibility of schizophrenia (SZ). A case-control study was performed to identify polymorphisms of the CA1, APH1A, NDEL1 and SRR gene that may confer susceptibility to SZ in the Han Chinese population. Five single nucleotide polymorphisms (SNPs) were genotyped in 516 paranoid SZ patients and 516 control subjects by real time quantitative polymerase chain reaction. The association between genotypes and positive and negative symptoms scale was also explored. No significant differences in genotype or allele frequencies of five SNPs were observed between schizophrenic patients and healthy controls (P = 0.163, 0.322, 0.494, 0.338, 0.545; 0.259, 0.149, 0.417, 0.527, 0.720; respectively). However, the frequency of CA haplotypes in SZ group was higher than control group (P = 0.041). The scores of depression/anx