Relationship between serum homocysteine level and oxidative stress in patients with obstructive sleep apnea-hypopnea syndrome

• Published in: Zhong hua yi xue za zhi Vol. 94; no. 32; p. 2510
• Main Authors: Li, Jie, Wang, Ling, Jiang, Min, Mao, Yanqing, Pan, Xudong
• Format: Journal Article
• Language: Chinese
• Published: China 26.08.2014
• Subjects: Biomarkers; Homocysteine; Humans; Malondialdehyde; Oxidative Stress; Oxygen; Polysomnography; Sleep Apnea, Obstructive
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2014.32.007

To explore the relationship between serum homocysteine (Hcy) level and oxidative stress in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Patients undergoing overnight full polysomnography (PSG) were selected from Sleep Disorders Center at First Affiliated Hospital between June 2008 and December 2013. A total of 117 OSAHS patients were recruited and divided into 3 groups of mild (n = 41), moderate (n = 40) and severe (n = 36). And they were compared with the controls (n = 33). The PSG variables were recorded and the contents of Hcy, malonaldehyde (MDA) and glutathione (GSH) detected after sleep. Serum Hcy was measured by cyclophorase. And MDA and GSH were measured by spectrophotometer. The concentrations of MDA in severe group were higher than those in the other three groups ((7.3 ± 1.0) vs (4.6 ± 0.9), (5.4 ± 1.3), (6.8 ± 0.7) µmol/L, all P < 0.05). The concentrations of GSH in mild and moderate groups were both higher than the controls ((6.5 ± 2.1), (7.5 ± 1.5) vs (4.2 ± 1.4) mg/L, all P <