Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition

The reduced hydration environment induced by disruption of epithelial barrier function after injury results in excessive scarring, but the underlying mechanisms are poorly understood. We demonstrated that exposing keratinocytes to a reduced hydration environment causes epithelial-to-mesenchymal tran...

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Published inAmerican journal of translational research Vol. 12; no. 12; pp. 8067 - 8083
Main Authors Yang, Shuai, Zhao, Jingling, Huang, Shixin, Shu, Bin, Yang, Ronghua, Chen, Lei, Xu, Yingbin, Xie, Julin, Liu, Xusheng, Jia, Ji, Qi, Shaohai
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2020
Subjects
Original
Caveolin-1
EMT
reduced hydration
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Summary:The reduced hydration environment induced by disruption of epithelial barrier function after injury results in excessive scarring, but the underlying mechanisms are poorly understood. We demonstrated that exposing keratinocytes to a reduced hydration environment causes epithelial-to-mesenchymal transition (EMT) and induces caveolin-1-dependent downregulation of E-cadherin. Reduced caveolin-1 expression and increased Snail expression are associated with low expression levels of E-cadherin. Caveolin-1 downregulation increases the transcriptional activity of β-catenin-TCF/LEF-1, and overexpression of caveolin-1 inhibits EMT that results from reduced hydration. Our findings suggest a role for caveolin-1 downregulation in linking aberrant EMT to the reduced hydration environment: findings that may lead to new developments in the prevention and treatment of hypertrophic scar.
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ISSN:1943-8141
1943-8141