Inhibition of human tumor cell induced platelet aggregation by antibodies to platelet glycoproteins Ib and IIb/IIIa

Tumor cell induced platelet aggregation was shown to be inhibited in a dose dependent manner by preincubation of human platelets with antibodies to platelet glycoprotein Ib and the IIb/IIIa complex. Combination of antibody to Ib and antibody to the IIb/IIIa complex at concentrations which produced h...

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Bibliographic Details
Published inProceedings of the Society for Experimental Biology and Medicine Vol. 186; no. 3; p. 378
Main Authors Grossi, I M, Fitzgerald, L A, Kendall, A, Taylor, J D, Sloane, B F, Honn, K V
Format Journal Article
LanguageEnglish
Published United States 01.12.1987
Subjects
Antibodies - immunology
Cell Line
Humans
Neoplasms - physiopathology
Platelet Aggregation - drug effects
Platelet Membrane Glycoproteins - immunology
Platelet Membrane Glycoproteins - physiology
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Summary:Tumor cell induced platelet aggregation was shown to be inhibited in a dose dependent manner by preincubation of human platelets with antibodies to platelet glycoprotein Ib and the IIb/IIIa complex. Combination of antibody to Ib and antibody to the IIb/IIIa complex at concentrations which produced half maximal inhibition of platelet aggregation alone caused complete inhibition of tumor cell induced platelet aggregation. Antibodies to platelet glycoproteins Ib and the IIb/IIIa complex also inhibited platelet synthesis of thromboxane A2, but not synthesis of 12-hydroxyeicosatrienoic acid. Inhibition of tumor cell induced platelet aggregation with antibodies against platelet glycoproteins suggests a role for these glycoproteins in tumor cell-platelet interactions and possibly platelet facilitated tumor cell metastasis.
ISSN:0037-9727
1525-1373