A Case of Rectal Cancer with Lymphangiosis Carcinomatosa Successfully Treated with Chemotherapy Despite Anaphylactic Reaction to Oxaliplatin

A 64-year-old man was admitted because of dyspnea. He was diagnosed with rectal cancer with lymphangiosis carcinomatosa and metastases in the liver and lymph nodes. The patient was treated with cetuximab and modified FOLFOX6 (mFOLFOX6). After treatment, the primary rectal cancer and metastases were...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 42; no. 13; p. 2481
Main Authors Ozaki, Kunihiro, Hayashida, Ryouzou, Nishi, Tatsuya, Ishibashi, Yoshiaki, Sakurai, Kanako, Nishimura, Yutaka, Akagi, Yoshito
Format Journal Article
LanguageJapanese
Published Japan 01.12.2015
Subjects
Anaphylaxis - chemically induced
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Lymphangitis - etiology
Male
Middle Aged
Organoplatinum Compounds - administration & dosage
Organoplatinum Compounds - adverse effects
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
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Summary:A 64-year-old man was admitted because of dyspnea. He was diagnosed with rectal cancer with lymphangiosis carcinomatosa and metastases in the liver and lymph nodes. The patient was treated with cetuximab and modified FOLFOX6 (mFOLFOX6). After treatment, the primary rectal cancer and metastases were considered to have achieved a partial response (PR) and the lymphangiosis carcinomatosa remarkably improved. However, anaphylactic shock occurred in the 6 courses of treatment, 5 minutes after the infusion of oxaliplatin, and the patient was treated.
ISSN:0385-0684