Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population

• Published in: Reports of biochemistry and molecular biology Vol. 7; no. 1; pp. 16 - 22
• Main Authors: Karimkhani, Sara, Chaleshi, Vahid, Balaii, Hedieh, Tarban, Peyman, Nourian, Mahyar, Irani, Shiva, Shahrokh, Shabnam, Asadzadeh Aghdaei, Hamid, Mohammad Alizadeh, Amir Houshang, Norouzinia, Mohsen, Zali, Mohammad Reza
• Format: Journal Article
• Language: English
• Published: Iran Varastegan Institute for Medical Sciences 01.10.2018
• Subjects: Original; Inflammatory bowel diseases; rs10889677; Interleukin 23 receptor; Crohn’s disease; Ulcerative colitis
• ISSN: 2322-3480; 2322-3480

Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in the interleukin-23R gene ( ) increase susceptibility to IBD. The aim of this study was to investigate the 3' UTR SNP to determine a potential association between genotype distribution and IBD. The case group included 102 IBD patients and the control group included 107 healthy individuals. polymorphisms rs10889677 were genotyped using PCR-RFLP analysis. RFLP results were confirmed by direct sequencing. The allele and genotype frequencies in patients and controls were evaluated and compared, and no significant association between this functional rs10889677 polymorphism and risk of IBD was observed (P=0.587; adjusted OR: 0.89; 95% CI: 0.597-1.339). We also found no significant association between CD (14.71%) and UC (85.29%) patients in allele or genotype levels (P>0.05). Our results suggest that the rs10889677 A>C polymorphism is not a potential prognostic marker in Iranian patients with IBD.