Clinical Implications and Appropriate Use of Amyloid Imaging with florbetapir ( 18 F) in Diagnosis of Patients with Alzheimer Disease

florbetapir ( F) is a radiolabeled compound that can be used to visualize amyloid-beta (Aβ) plaques in the brains of patients with cognitive dysfunction, who are suspected of having Alzheimer disease (AD). Knowing the status of Aβ accumulation in the brain is beneficial to selecting therapeutic stra...

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Published inBrain and nerve = Shinkei kenkyū no shinpo Vol. 68; no. 10; p. 1215
Main Authors Nakamura, Tomomi, Iwata, Atsushi, Ueda, Kaname, Namiki, Chihiro
Format Journal Article
LanguageJapanese
Published Japan 01.10.2016
Subjects
Alzheimer Disease - diagnostic imaging
Amyloid - analysis
Aniline Compounds
Biomarkers - analysis
Ethylene Glycols
Fluorine Radioisotopes
Humans
Radiopharmaceuticals
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Summary:florbetapir ( F) is a radiolabeled compound that can be used to visualize amyloid-beta (Aβ) plaques in the brains of patients with cognitive dysfunction, who are suspected of having Alzheimer disease (AD). Knowing the status of Aβ accumulation in the brain is beneficial to selecting therapeutic strategies or to planning of laboratory examinations, hence amyloid PET imaging is expected to be utilized more often in a clinical setting. Based on the results of a clinical study of florbetapir ( F), this review discusses the usefulness and clinical significance of amyloid PET imaging, and its appropriate use in Japan. (Received Octover 7, 2015; Accepted February 15, 2016; Published October 1, 2016).
ISSN:1881-6096