Analysis of the influencing factors of the clinical effect of respiratory humidifier in treating AIDS complicated with severe Pneumocystis jiroveci pneumonia

• Published in: American journal of translational research Vol. 13; no. 12; pp. 13967 - 13973
• Main Authors: Cao, Qi, Zeng, Wei, Nie, Jingmin, Ye, Yongjun, Chen, Yanchao
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2021
• Subjects: Original; AIDS; clinical; Pneumocystis jiroveci pneumonia; respiratory humidifier
• ISSN: 1943-8141; 1943-8141

To analyze the factors influencing the clinical effect of using respiratory humidifier in patients with AIDS complicated with severe Pneumocystis jiroveci pneumonia (PCP). According to the treatment results, AIDS patients with severe PCP were divided into two groups, successful group (n=68) and failure group (n=94), to compare the early ventilation changes between the two groups. The ICU ratio of the successful group was lower than that of the failure group ( <0.05). The respiratory frequency, heart rate, PaO , C-reactive protein and SOFA score of the successful group were lower than those in the failure group ( <0.05), while SpO , FiO , PaO /FiO , SpO /FiO , Rox index and IL-10 levels were increased in the successful group ( <0.05). The successful group had higher IL-6 and IL-1β level than that of the failure group. The levels of IL-8 were decreased ( <0.05). The success of respiratory humidifier was negatively correlated with the score of SOFA ( <0.05). The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO /FiO , PaO , ROX index, SOFA score, and IL-6 and IL-8 levels.