Exosome mediated multidrug resistance in cancer

Extracellular vesicles (EVs), named as exosomes, were recently found to play important roles in cell-cell communication by transducing various biochemical and genetic information. Exosomes, secreted from either tumor cells or stromal cells including immune cells, can eventually remodel tumor environ...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of cancer research Vol. 8; no. 11; pp. 2210 - 2226
Main Authors Yousafzai, Neelum Aziz, Wang, Hanying, Wang, Zhuo, Zhu, Yiran, Zhu, Liyuan, Jin, Hongchuan, Wang, Xian
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2018
Subjects
Review
multidrug resistance
Exosomes
immune suppression
signal transduction
chemotherapy
Online AccessGet full text

Cover

More Information
Summary:Extracellular vesicles (EVs), named as exosomes, were recently found to play important roles in cell-cell communication by transducing various biochemical and genetic information. Exosomes, secreted from either tumor cells or stromal cells including immune cells, can eventually remodel tumor environment to promote tumor progression such as metastasis and multidrug resistance (MDR). Therefore, the detection or targeting of biochemical and genetic cargos like proteins, lipids, metabolites and various types of RNAs or DNAs are believed to be valuable for the diagnosis and treatment of human cancer. In this review, we will summarize recent progresses in the research of exosomes especially its biological and clinical relevance to MDR. By doing so, we hope it could be valuable for the prevention, detection and intervention of MDR which is one of the major challenges for the clinical management of human cancers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2156-6976
2156-6976