Uncommon Epoxyquinols Pyrrolocytosporin A and Cytosporin E2 from the Fungus Eutypella sp. D‐1

Two uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic‐derived fungus Eutypella sp. D‐1. Their structures were established through comprehensive analyses of spectroscopic and electron...

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Published inChemistry & biodiversity Vol. 21; no. 8; pp. e202401097 - n/a
Main Authors Yu, Hao‐Bing, Du, Lin, Ning, Zhe, Lu, Xiao‐Ling, Jiao, Bing‐Hua, Hu, Bo, Liu, Xiao‐Yu
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.08.2024
Subjects
Anti-inflammatory activity
Cell proliferation
Circular dichroism
Concanavalin A
Cytosporin
Cytotoxicity
Dichroism
Epoxyquinol
Eutypella sp. D-1
Fungi
Immunosuppressive activity
Lipopolysaccharides
Metabolites
Nitric oxide
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Summary:Two uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic‐derived fungus Eutypella sp. D‐1. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound 1 represented the first nitrogen‐containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound 2 contained an uncommon cyclic carbonate functionality. The antibacterial, immunosuppressive, anti‐inflammatory, and cytotoxic activities of all compounds were evaluated. Among the three metabolites, only compound 1 exhibited inhibitory effects on nitric oxide production induced by lipopolysaccharide with an IC50 value of 6.55 μM. Additionally, only compound 2 displayed inhibitory activity against ConA‐induced T‐cell proliferation with an IC50 value of 9.85 μM.
Bibliography:These authors contribute equally to this work.
ObjectType-Article-1
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content type line 23
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202401097