Effects of combined enteral nutrition support on hemorrheologic parameters and the level of inflammatory factors in rabbits with severe acute pancreatitis

• Published in: Zhong hua yi xue za zhi Vol. 91; no. 28; p. 2006
• Main Authors: Yan, Qiang, Ni, Jun, Zhang, Guo-lei, Yuan, Wen-bin, Ping, Jin-liang, Jin, Wen-jun
• Format: Journal Article
• Language: Chinese
• Published: China 26.07.2011
• Subjects: Animals; Enteral Nutrition; Interleukin-8 - metabolism; Pancreatitis, Acute Necrotizing - blood; Pancreatitis, Acute Necrotizing - metabolism; Parenteral Nutrition; Rabbits; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2011.28.017

To explore the effects of combined enteral nutrition (CEN) on the hemorheologic parameters and the changing levels of inflammatory factors in an animal model of severe acute pancreatitis (SAP). The experimental animals were divided randomly into 3 groups, i.e. early enteral nutrition (EEN) group, CEN group and parenteral nutrition(PN)group (n = 20 each). Enteral nutrition was administered to the EEN and CEN group animals at 24 h and 72 h post-modeling respectively. The PN group animals were supported by parenteral nutrition all time. Hemorrheologic indices of all experimental animals were examined on Days 1, 3 and 7 post-modeling. And the inflammatory factors were examined on Days 1 and 7. Compared with the EEN and PN groups, some hemorrheologic indices of the CEN group decreased significantly (P < 0.05) on Day 7 post-modeling. They included blood sedimentation, hematocrit (HCT), whole blood high-cut reduction viscosity and whole blood low-cut reduction viscosity. As compared within the CEN group, each hemorr