Clinical diagnosis and treatment of BK virus infection in renal transplant recipients

• Published in: Zhong hua yi xue za zhi Vol. 88; no. 26; p. 1824
• Main Authors: Chen, Li-zhong, Huang, Gang, Qiu, Jiang, Li, Jun, Chen, Guo-dong, Zeng, Wen-tao, Fu, Qian, Zhang, Lei, Ji, Yu-lian
• Format: Journal Article
• Language: Chinese
• Published: China 08.07.2008
• Subjects: Adolescent; Adult; BK Virus - genetics; DNA, Viral - urine; Female; Humans; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Male; Middle Aged; Polyomavirus Infections - diagnosis; Polyomavirus Infections - therapy; Polyomavirus Infections - virology; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Postoperative Complications - therapy; Tumor Virus Infections - diagnosis; Tumor Virus Infections - therapy; Tumor Virus Infections - virology; Young Adult
• ISSN: 0376-2491

To explore methods of clinical diagnosis and treatment of BK virus (BKV) infection in renal transplant recipients. Urine samples were collected from 227 renal transplant recipients who had undergone renal transplantation at most 48 months to detect the decoy cells. Samples of urine and peripheral blood (BP) were collected to undergo real-time PCR to detect the BKV DNA. Part of the renal-recipients received graft biopsy. The recipients with BKV viruria or viremia were divided into 2 groups: intervention group and control group. The 51 patients of the intervention group had the doses of cyclosporine A (CsA) reduced (n=19), had their doses of FK506 reduced (n=22), or underwent replacement of FK506 with CsA (n=10). And other 29 patients in the control group did not receive any intervention. Acute rejection was intensively monitored. The amount of decoy cells, and BKV load in the urine and PB samples were measured again after 3 months. The positive rates of urine decoy cell, BKV viruria, and viremia in all patient