In vivo effect of nanophase Ti6Al4V on osseointegration: experiment with rabbits

To evaluate the effect of nanophase Ti6Al4V substrates on the osseointegration in vivo. Novel nanophase Ti6Al4V substrates were prepared according to the severe plastic deformation principle. Eighteen New Zealand white rabbits were randomly divided into 3 equal groups with their trochanters of femur...

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Bibliographic Details
Published inZhong hua yi xue za zhi Vol. 88; no. 25; p. 1767
Main Authors Han, Pei, Ji, Wei-Ping, Jiang, Yao, Zhao, Chang-Li, Zhang, Xiao-Nong
Format Journal Article
LanguageChinese
Published China 01.07.2008
Subjects
Animals
Femur - drug effects
Femur - physiopathology
Femur - ultrastructure
Implants, Experimental
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanostructures - chemistry
Nanostructures - ultrastructure
Osseointegration - drug effects
Rabbits
Random Allocation
Titanium - chemistry
Titanium - pharmacology
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Summary:To evaluate the effect of nanophase Ti6Al4V substrates on the osseointegration in vivo. Novel nanophase Ti6Al4V substrates were prepared according to the severe plastic deformation principle. Eighteen New Zealand white rabbits were randomly divided into 3 equal groups with their trochanters of femur exposed and implanted with titanium substrate with common surface (Ti group), nanophase Ti6Al4V substrate (nano-Ti group), and hydroxyapatite-coated substrate (HA group) respectively. Four, 8, and 12 weeks later X-ray films were taken on 6 rabbits from each group, tetracycline and calcein were injected intramuscularly, and one day later the rabbits were sacrificed. The histological changes of the tissue surrounding the implant including the bone kinesics parameter were evaluated; the bone-implant interfaces were examined with scanning electron microscope (SEM) and transmission electron microscope (TEM) respectively. Radiographic examinations showed that the bone recovery around the implant in the nano-Ti group was
ISSN:0376-2491