Cardiovascular Toxicities of Immunosuppressive Agents

Cardiovascular disease is one of the major causes of morbidity and mortality following solid organ transplantation. Many of the current immunosuppressive drugs are associated with an increase of one or more risk factors for the development of atherosclerosis. This review compares the mechanism by wh...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of transplantation Vol. 2; no. 9; pp. 807 - 818
Main Author Miller, Leslie W.
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.10.2002
Subjects
Adrenal Cortex Hormones - toxicity
Animals
Cardiovascular System - physiopathology
Cardiovascular toxicity
Coronary Artery Disease - physiopathology
Cyclosporine - toxicity
Diabetes Mellitus - physiopathology
Humans
Hyperlipidemias - physiopathology
Hypertension - physiopathology
immunosuppressants
Immunosuppressive Agents - toxicity
organ transplantation
Sirolimus - toxicity
Tacrolimus - toxicity
Online AccessGet full text

Cover

More Information
Summary:Cardiovascular disease is one of the major causes of morbidity and mortality following solid organ transplantation. Many of the current immunosuppressive drugs are associated with an increase of one or more risk factors for the development of atherosclerosis. This review compares the mechanism by which individual immunosuppressive agents may impact on these risk factors and the differential contributionof cyclosporine, tacrolimus, mycophenolate, azathioprine, and Rapamycin to these individual risk factors. Attention to the potential cardiovascular toxicities of individual immunosuppressive agents may help design strategies for maintenance of immunosuppression tailored to individual patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:1600-6135
1600-6143
DOI:10.1034/j.1600-6143.2002.20902.x