Elucidation of the mTOR Pathway and Therapeutic Applications in Dermatology

• Published in: Actas dermo-sifiliográficas (English ed.) Vol. 107; no. 5; pp. 379 - 390
• Main Authors: Salido-Vallejo, R, Garnacho-Saucedo, G, Vélez, A
• Format: Journal Article
• Language: English; Spanish
• Published: 01.06.2016
• ISSN: 1578-2190
• DOI: 10.1016/j.ad.2015.12.006

The member of the phosphatidylinositol 3-kinase family, mammalian target of rapamycin, is involved in modulating inflammatory response and regulating cellular processes associated with growth, differentiation, and angiogenesis. Recent years have seen major advances in our understanding of the mammalian target of rapamycin signaling pathway and the implication of this pathway in multiple genetic and inflammatory diseases and tumors. The development of the mammalian target of rapamycin inhibitors has given rise to new treatment approaches that have led to substantially improved outcomes in many diseases. In this article, we review the role of the mammalian target of rapamycin signaling pathway in the different skin diseases with which it has been associated, examine the therapeutic applications of drugs targeting this pathway, and provide an overview of current trends and future directions in research.