Patients selection for psychiatric neurosurgery: pitfalls and considerations

• Published in: Progress in brain research Vol. 272; no. 1; pp. 173 - 183
• Main Authors: Zaitsev, Oleg S, Poddubskaya, Anna A, Tomskiy, Alexey A, Gamaleya, Anna A, Maksakova, Olga A, Potapov, Igor V, Tsukarzi, Eduard E, Mosolov, Sergey N
• Format: Journal Article
• Language: English
• Published: Netherlands 2022
• Subjects: Psychiatry; Psychiatric neurosurgery
• ISSN: 1875-7855
• DOI: 10.1016/bs.pbr.2022.03.011

Neurosurgical interventions (destructive or neuromodulation) are considered as a therapeutic option for patients with treatment resistant mental disorders. However, the issues of indications and contraindications for psychiatric surgery, method and patient selection remain unresolved. This article discusses possible problems and contradictions in the selection of patients, the need for an interdisciplinary team to work to solve the question of the feasibility of using neurosurgical methods. The authors have identified the main problems that increase the risks of selection and lead to a lack of results or low efficiency of neurosurgical intervention, namely: (1) diagnostic errors or inaccuracies; (2) inconclusive data on therapeutic resistance; (3) lack of a common understanding of the goals and desired results among participants in the selection of patients for neurosurgery. Possible predictors of surgical outcome and ethical issues are also discussed. Neurosurgical interventions as a treatment option for psychiatric disorders are not officially approved in most countries. So an appropriate algorithm for patient selection and clear criteria for outcome measures are needed.