Organ donation and organ assessment after primary circulatory death and secondary brain death

• Published in: Chirurgie (Heidelberg, Germany) Vol. 95; no. 8; p. 618
• Main Authors: Müller, Philip C, Müller, Beat P, Dutkowski, Philipp
• Format: Journal Article
• Language: German
• Published: Germany 01.08.2024
• Subjects: Brain Death - legislation & jurisprudence; Europe; Humans; Liver Transplantation; Tissue and Organ Procurement - legislation & jurisprudence; Tissue Donors - statistics & numerical data; Tissue Donors - supply & distribution; Europe; Hypothermic oxygenated machine perfusion; Ethical aspects; Legal aspects; Liver transplantation; Organ shortage
• ISSN: 2731-698X; 2731-698X
• DOI: 10.1007/s00104-024-02094-x

The global organ shortage is the biggest obstacle to expand urgently needed liver transplantation activities. In addition to donation after brain death (DBD), donation after primary circulatory death (DCD) has also been introduced in many European countries to increase the number of donated organs. This article summarizes the legal and ethical aspects of DCD, the practical donation process of DCD, the clinical results of DCD liver transplantation with a special focus on organ assessment before a planned DCD liver transplantation. In Europe 11 countries have active DCD liver transplantation programs and a total of 1230 DCD liver transplantations were performed in Europe in 2023. The highest proportion of DCD liver transplantations were recorded in Belgium (52.8%), the Netherlands (42.8%) and Switzerland (32.1%). The adequate selection of donors and recipients is crucial in DCD transplantation and the use of DCD livers particularly depends on the preparedness of the healthcare system for routine machine perfusion. The leaders are Belgium, France and Italy which implant around 68-74% of DCD organs. With an adequate organ assessment, the long-term results of DBD and DCD liver transplantations are comparable. To assess mitochondrial damage and thus organ quality, hypothermic oxygenated machine perfusion (HOPE) was introduced and has the secondary benefit of mitochondrial protection through oxygenation. The establishment of aerobic metabolism in mitochondria under hypothermia leads to a reduction of toxic metabolites and the restoration of ATP storage, which subsequently leads to a reperfusion light during implantation. Expanding the donor pool with DCD donors can counteract the global organ shortage. With adequate patient selection and routine organ assessment short-term and also long-term outcomes of DBD and DCD liver transplantation are comparable.