Human CYPIAI gene: Cosegregation of the enzyme inducibility phenotype and an RFLP

The human CYP1A1 (cytochrome P sub(1)450) gene encodes an enzyme involved in the activation of procarcinogens, such as benzo(a)pyrene, to the ultimate reactive intermediate. In one 3-generation family of 15 individuals, we show here that the high-CYP1A1-inducibility phenotype segregates concordantly...

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Published inAmerican journal of human genetics Vol. 48; no. 4; pp. 720 - 725
Main Authors Petersen, D D, McKinney, CE, Ikeya, K, Smith, H H, Bale, A E, McBride, O W, Nebert, D W
Format Journal Article
LanguageEnglish
Published 1991
Subjects
genes
restriction fragment length polymorphism
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Summary:The human CYP1A1 (cytochrome P sub(1)450) gene encodes an enzyme involved in the activation of procarcinogens, such as benzo(a)pyrene, to the ultimate reactive intermediate. In one 3-generation family of 15 individuals, we show here that the high-CYP1A1-inducibility phenotype segregates concordantly with an infrequent polymorphic site located 450 bases downstream from the CYP1A1 gene. Our findings are consistent with the study of Kawajiri et al., who demonstrated an association between this polymorphism and an increased incidence of squamous-cell lung cancer.
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ISSN:0002-9297