Ultraviolet radiation-induced murine tumors produced in the absence of ultraviolet radiation-induced systemic tumor immunosuppression

• Published in: Cancer research (Chicago, Ill.) Vol. 51; no. 11; pp. 2773 - 2779
• Main Authors: Menzies, S W, Greenoak, GE, Reeve, V E, Gallagher, CH
• Format: Journal Article
• Language: English
• Published: 1991
• ISSN: 0008-5472

Using micro-UV-irradiation versus whole-dorsal irradiation for inducing cutaneous carcinomas in Skh:HRI mice and an assay for UV radiation (UVR)-induced systemic tumor immunosuppression, the dependence upon systemic immunosuppression for the growth of UVR-induced carcinomas was examined. The observations provide evidence that UVR-induced systemic tumor immunosuppression is not necessary for the production of UVR-induced tumors. However, it does cause a positive selection pressure during tumor formation, independent of the carcinogenic effect of UVR, which affects the transplantation biology of a tumor.