Action of the chloroquine/pyrimethamine combination on southern African isolates of Plasmodium falciparum in vitro

The action of the chloroquine/pyrimethamine combination on southern African isolates of Plasmodium falciparum was investigated in vitro using the isotope incorporation method. Resistance to both chloroquine and pyrimethamine was confirmed in the three isolates tested. The sums of relative IC sub(50)...

Full description

Saved in:
Bibliographic Details
Published inSouth African journal of science Vol. 93; no. 6; pp. 295 - 296
Main Authors Tsoka, J M, Freese, JA, Rossouw, E J, Sharp, B L, Appleton, C C
Format Journal Article
LanguageEnglish
Published 01.06.1997
Subjects
Freshwater
Plasmodium falciparum
Online AccessGet full text

Cover

More Information
Summary:The action of the chloroquine/pyrimethamine combination on southern African isolates of Plasmodium falciparum was investigated in vitro using the isotope incorporation method. Resistance to both chloroquine and pyrimethamine was confirmed in the three isolates tested. The sums of relative IC sub(50) values for all three isolates indicated an antagonistic action between chloroquine and pyrimethamine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0038-2353