CONJUGATION OF A POLYAMINE TO THE BIFUNCTIONAL ALKYLATING AGENT CHLORAMBUCIL DOES NOT ALTER THE PREFERRED CROSS-LINKING SITE IN DUPLEX DNA
We report here that chlorambucil introduces interstrand cross-links preferentially between two guanine residues in the sequence 5'-GNC, as has been observed for mechlorethamine and in line with the prediction of Millard et al. We also report that the site of cross-linking is not perturbed when...
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Published in | Journal of the American Chemical Society Vol. 117; no. 30; pp. 8033 - 8034 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
Amer Chemical Soc
02.08.1995
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Subjects | |
Online Access | Get full text |
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Summary: | We report here that chlorambucil introduces interstrand cross-links preferentially between two guanine residues in the sequence 5'-GNC, as has been observed for mechlorethamine and in line with the prediction of Millard et al. We also report that the site of cross-linking is not perturbed when chlorambucil is conjugated to either spermidine or spermine to give conjugates 2 and 3, respectively. The results have important implications for the nature of interaction between DNA and polyamines. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0002-7863 |
DOI: | 10.1021/ja00135a029 |