CONJUGATION OF A POLYAMINE TO THE BIFUNCTIONAL ALKYLATING AGENT CHLORAMBUCIL DOES NOT ALTER THE PREFERRED CROSS-LINKING SITE IN DUPLEX DNA

We report here that chlorambucil introduces interstrand cross-links preferentially between two guanine residues in the sequence 5'-GNC, as has been observed for mechlorethamine and in line with the prediction of Millard et al. We also report that the site of cross-linking is not perturbed when...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 117; no. 30; pp. 8033 - 8034
Main Authors CULLIS, PM, MERSONDAVIES, L, WEAVER, R
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 02.08.1995
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CELLS
DEOXYGUANOSINE RESIDUES
SPERMIDINE CONJUGATE
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Summary:We report here that chlorambucil introduces interstrand cross-links preferentially between two guanine residues in the sequence 5'-GNC, as has been observed for mechlorethamine and in line with the prediction of Millard et al. We also report that the site of cross-linking is not perturbed when chlorambucil is conjugated to either spermidine or spermine to give conjugates 2 and 3, respectively. The results have important implications for the nature of interaction between DNA and polyamines.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0002-7863
DOI:10.1021/ja00135a029