Photoinduced C-H heteroarylation of enamines via quadruple cleavage of CF2Br2

The C-H functionalization of enamines has attracted much attention over the past few years; however, the heteroarylation of enamines still remains rare. Herein, we wish to report a photoinduced three-component coupling/cyclization reaction for the de novo synthesis of 1,3,4-oxdiazole- or benzothiazo...

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Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 24; pp. 6112 - 6116
Main Authors Zuo, Wanqing, Zuo, Lingling, Geng, Xiao, Li, Zhifang, Wang, Lei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 05.12.2023
Royal Society of Chemistry
Subjects
Benzothiazole
Chemistry
Chemistry, Organic
Cleavage
Organic chemistry
Physical Sciences
Science & Technology
ALKENES
BOND FORMATION
ACYLOXYLATION
CYCLIZATION
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Summary:The C-H functionalization of enamines has attracted much attention over the past few years; however, the heteroarylation of enamines still remains rare. Herein, we wish to report a photoinduced three-component coupling/cyclization reaction for the de novo synthesis of 1,3,4-oxdiazole- or benzothiazole-functionalized enamines via quadruple cleavage of CF2Br2. Notably, the reaction provides an efficient and general approach for the C-H heteroarylation of enamines and exploits a new reactivity of CF2Br2, as the C1 source.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d3qo01474f