Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate

A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their effic...

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Published inOrganic communications Vol. 8; no. 2; p. 43
Main Authors Badvel, Sreedhar, Veera Reddy Tummaluru, Venugopal Reddy Katta, Vidya Sagar Reddy Gandi, Naga Raju Chamarthi, Padmavathi Venkatapuram
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.04.2015
Subjects
Antimicrobial agents
Chemical compounds
Inhibitor drugs
Pharmaceutical sciences
Uric acid
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Summary:A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their efficacy as antimicrobial agents in vitro by disc diffusion method. Compounds 4c, 4f, 4g and 4i showed high inhibitory activity.
ISSN:1307-6175