Pulmonary squamous cell carcinoma in a captive clouded leopard (Neofelis nebulosa)

A female, 5-year-old clouded leopard died three days after showing clinical signs of lethargy and loss of appetite. Macroscopically, multiple, firm, nodular masses were found randomly in the caudal lobes of the lungs. There were no metastatic lesions on the skin. Histopathological examination demons...

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Published inWētchasān sattawaphāet Vol. 49; no. 3; pp. 309 - 312
Main Authors Boonsri, Kittikorn, Pothichai, Koravee, Vechmanus, Thewarach, Boonthong, Pinich, Pringproa, Kidsadagon
Format Journal Article
LanguageEnglish
Published Bangkok Chulalongkorn University, Faculty of Veterinary Science 01.09.2019
Subjects
Air pollution
Animals
Appetite loss
Cats
Cytokeratin
Immunoglobulins
Immunohistochemistry
Keratin
Laboratories
Lung cancer
Lung carcinoma
Metastases
Metastasis
Skin diseases
Squamous cell carcinoma
Tumors
Veterinary medicine
Vimentin
Thailand
United States > US
California
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Summary:A female, 5-year-old clouded leopard died three days after showing clinical signs of lethargy and loss of appetite. Macroscopically, multiple, firm, nodular masses were found randomly in the caudal lobes of the lungs. There were no metastatic lesions on the skin. Histopathological examination demonstrated multifocal trabeculae and a nest of large, variable sized of squamous epitheliums. Multifocal keratin pearls were also randomly seen in the masses. No metastasis was found in the other internal organs. Immunohistochemically revealed that the neoplastic cells were immunoreactivity positive for cytokeratin, while negative for vimentin. Based on the histopathology and immunohistochemistry, pulmonary squamous cell carcinoma (SCC) was diagnosed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0125-6491