L-proline catalyzed an efficient multicomponent one-pot synthesis of poly substituted pyridines

A series of poly substituted pyridines (3,11-disubstituted-7-aryl-5,6,8,9-tetrahydro-dibenzo[c,h]acridines) were synthesized by the multicomponent condensation of 6-substituted-1-tetralone, aromatic aldehydes and ammonium acetate in ethanol using L-proline as an efficient organocatalyst. This method...

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Bibliographic Details
Published inOrganic communications Vol. 5; no. 4; p. 186
Main Authors Janardhan, B, Ravibabu, V, Crooks, Peter A, Rajitha, B
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.10.2012
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Summary:A series of poly substituted pyridines (3,11-disubstituted-7-aryl-5,6,8,9-tetrahydro-dibenzo[c,h]acridines) were synthesized by the multicomponent condensation of 6-substituted-1-tetralone, aromatic aldehydes and ammonium acetate in ethanol using L-proline as an efficient organocatalyst. This methodology is mild, efficient, high yielding and the catalyst is inexpensive, easily recovered from the reaction mixture and reused for five times without losing its activity.
ISSN:1307-6175