The New Alkaloids from Antidesma cuspidatum M.A

Two new alkaloids, cuspidatin (1) and cuspidatinol (2), were isolated from Antidesma cuspidatum M.A. (Euphorbiaceae). The structures were determined by means of spectroscopic analysis (IR, MS, and NMR spectroscopy). The results of cytotoxicity evaluation showed that compounds 1 and 2 were inhibitory...

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Bibliographic Details
Published inRecords of natural products Vol. 8; no. 4; p. 342
Main Authors Elya, Berna, estrania, Roshamur C, Ropi, Mat, Kosela, Soleh, Awang, Khalijah, Hanita Omar, Hadi, A Hamid A
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.01.2014
Subjects
Cancer
Chemical research
Chemistry
Chromatography
Cytotoxicity
Herbal medicine
Leukemia
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Summary:Two new alkaloids, cuspidatin (1) and cuspidatinol (2), were isolated from Antidesma cuspidatum M.A. (Euphorbiaceae). The structures were determined by means of spectroscopic analysis (IR, MS, and NMR spectroscopy). The results of cytotoxicity evaluation showed that compounds 1 and 2 were inhibitory to L1210 cells, with IC 50 values 8.41 and 6.36 µg/mL respectively.
ISSN:1307-6167