Expression of receptors for human alpha- and gamma-interferons on the surface of peripheral blood mononuclear cells in viral infections

Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these inter...

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Published inVoprosy virusologiĭ Vol. 44; no. 1; p. 16
Main Authors Barkova, E P, Nagieva, F G, Kuznetsov, V P, Beliaev, D L, Nikulina, V G, Babaiants, A A, Krel', P E, Andzhaparidze, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1999
Subjects
Animals
Antibodies, Anti-Idiotypic - immunology
Antibodies, Monoclonal - immunology
Chlorocebus aethiops
Humans
Interferon gamma Receptor
Leukocytes, Mononuclear - immunology
Receptor, Interferon alpha-beta
Receptors, Interferon - immunology
Vero Cells
Virus Diseases - immunology
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Abstract Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these interferons. Activation of the immune system caused by infection modifies the expression of interferon receptors and leads to appearance of membrane-bound interferons, mainly gamma-interferon.
AbstractList Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these interferons. Activation of the immune system caused by infection modifies the expression of interferon receptors and leads to appearance of membrane-bound interferons, mainly gamma-interferon.
Author Babaiants, A A
Nagieva, F G
Krel', P E
Barkova, E P
Beliaev, D L
Andzhaparidze, O G
Kuznetsov, V P
Nikulina, V G
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DocumentTitleAlternate Ekspressiia retseptorov dlia chelovecheskikh alpha- i gamma-interferonov na poverkhnosti mononuklearnykh kletok perifericheskoĭ krovi pri virusnykh infektsiiakh
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Snippet Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal...
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StartPage 16
SubjectTerms Animals
Antibodies, Anti-Idiotypic - immunology
Antibodies, Monoclonal - immunology
Chlorocebus aethiops
Humans
Interferon gamma Receptor
Leukocytes, Mononuclear - immunology
Receptor, Interferon alpha-beta
Receptors, Interferon - immunology
Vero Cells
Virus Diseases - immunology
Title Expression of receptors for human alpha- and gamma-interferons on the surface of peripheral blood mononuclear cells in viral infections
URI https://www.ncbi.nlm.nih.gov/pubmed/10190235
Volume 44
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