Expression of receptors for human alpha- and gamma-interferons on the surface of peripheral blood mononuclear cells in viral infections

Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these inter...

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Published inVoprosy virusologiĭ Vol. 44; no. 1; p. 16
Main Authors Barkova, E P, Nagieva, F G, Kuznetsov, V P, Beliaev, D L, Nikulina, V G, Babaiants, A A, Krel', P E, Andzhaparidze, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1999
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Summary:Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these interferons. Activation of the immune system caused by infection modifies the expression of interferon receptors and leads to appearance of membrane-bound interferons, mainly gamma-interferon.
ISSN:0507-4088