A FORMAL TOTAL SYNTHESIS OF (+/-)-FORSKOLIN THROUGH [3+2] NITRILE OXIDE CYCLOADDITION CHEMISTRY

A formal synthesis of (+/-)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework...

Full description

Saved in:
Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 46; no. 11; pp. 1281 - 1295
Main Authors BARCO, A, BENETTI, S, SPALLUTO, G, CASOLARI, A, POLLINI, GP, ZANIRATO, BARALDI, PG
Format Journal Article
LanguageEnglish
Published ROME Soc Chimica Italiana 01.11.1991
Subjects
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
ROUTE
FORSKOLIN
INTERMEDIATE
Online AccessGet more information

Cover

More Information
Summary:A formal synthesis of (+/-)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework required for assembling the pyranone unit. The synthetic sequence constitues a new synthetic route to the natural target since the enone 29 has been previously converted to (+/-)-forskolin.
ISSN:0014-827X