(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 41; no. 9; pp. 1357 - 1360
Main Authors Wishka, DG, Graber, DR, Kopta, LA, Olmsted, RA, Friis, JM, Hosley, JD, Adams, WJ, Seest, EP, Castle, TM, Dolak, LA, Keiser, BJ, Yagi, Y, Jeganathan, A, Schlachter, ST, Murphy, MJ, Cleek, GJ, Nugent, RA, Poppe, SM, Swaney, SM, Han, FS, Watt, W, White, WL, Poel, TJ, Thomas, RC, Voorman, RL, Stefanski, KJ, Stehle, RG, Tarpley, WG, Morris, J
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 23.04.1998
American Chemical Society
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Chemistry, Medicinal
Life Sciences & Biomedicine
Medical sciences
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Science & Technology
IMMUNODEFICIENCY-VIRUS TYPE-1
RESISTANCE
U-90152S
POTENT
DERIVATIVES
BIS(HETEROARYL)PIPERAZINES
Intravenous administration
Rat
HIV-1 virus
Non nucleoside compound
Chlorine Organic compounds
Bicyclic compound
Antiviral
Chemical synthesis
Enantiomer(-)
Oxygen nitrogen heterocycle
Rodentia
Single dose
Oral administration
Retroviridae
Lentivirus
Biological activity
Delavirdine
Virus
Resistance
Vertebrata
Mammalia
Animal
S configuration
Pyrimidine derivatives
Human immunodeficiency virus
Pharmacokinetics
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm9801049