Angioimmunoblastic lymphadenopathy with trisomy 3: the cells of the malignant clone are T cells

A method involving simultaneous demonstration of the immunophenotype and the karyotype was applied to a case of angioimmunoblastic lymphadenopathy (AILD), in which the standard chromosome preparation revealed an aberrant clone with trisomy 3 and additional changes. The aberrant mitoses showed a posi...

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Bibliographic Details
Published inHematologic pathology Vol. 4; no. 4; p. 179
Main Authors Schlegelberger, B, Nölle, I, Feller, A C, Bauer, E, Grote, W
Format Journal Article
LanguageEnglish
Published United States 1990
Subjects
Chromosomes, Human, Pair 3
Humans
Immunoblastic Lymphadenopathy - genetics
Immunoblastic Lymphadenopathy - immunology
Immunophenotyping
Karyotyping
Lymphoma, T-Cell - genetics
Male
Middle Aged
Trisomy
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Summary:A method involving simultaneous demonstration of the immunophenotype and the karyotype was applied to a case of angioimmunoblastic lymphadenopathy (AILD), in which the standard chromosome preparation revealed an aberrant clone with trisomy 3 and additional changes. The aberrant mitoses showed a positive reaction with the monoclonal T-cell antibody Leu 4 (CD3). This new method thus provides definite evidence that the malignant clone with trisomy 3, a characteristic finding in AILD, belongs to the T-cell population. Nevertheless, cytogenetically normal T cells were also found. Moreover, a cell from the same clone was found in the phytohemagglutinin-stimulated blood lymphocytes. This finding demonstrates that AILD may have a leukemic variant.
ISSN:0886-0238