Synthetic approaches towards 1 H-pyrrolo[1,2-c]imidazoles

A novel synthetic approach towards 1,2-disubstituted-2,3-dihydro-1 H-pyrrolo[1,2-c]imidazol-3-ones or thiones 3a-i was accomplished via the base catalyzed addition of aryl and alkyl isocyanates or their thio-analogues to 1-aryl-3-(1 H-pyrrol-2-yl)-2-propen-1-ones 1a, b. However, isocyanate electroph...

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Bibliographic Details
Published inPharmazie Vol. 53; no. 9; pp. 607 - 611
Main Authors Mishriky, N, Asaad, FM, Ibrahim, YA, Girgis, AS
Format Journal Article
LanguageEnglish
Published ESCHBORN GOVI-VERLAG GMBH 01.09.1998
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
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Summary:A novel synthetic approach towards 1,2-disubstituted-2,3-dihydro-1 H-pyrrolo[1,2-c]imidazol-3-ones or thiones 3a-i was accomplished via the base catalyzed addition of aryl and alkyl isocyanates or their thio-analogues to 1-aryl-3-(1 H-pyrrol-2-yl)-2-propen-1-ones 1a, b. However, isocyanate electrophilic attack to N-(1 H-pyrrol-2-ylmethylene)benzenamines 5a, b afforded the corresponding open-chain adducts 6a,b. The tatters could be cyclized to 1 H-pyrrolo[l,2-c]imidazoles 8 under base-catalyzed or uncatalyzed conditions. The molluscicidal activity of the products was screened.
ISSN:0031-7144