Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases : determinants for different in vivo activities of GI198745 and finasteride in the rat

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Bibliographic Details
Published inBiochemical pharmacology Vol. 62; no. 7; pp. 933 - 942
Main Authors STUART, J. Darren, LEE, Frank W, BRAMSON, H. Neal, NOEL, Deborah Simpson, KADWELL, Sue H, OVERTON, Laurie K, HOFFMAN, Christine R, KOST, Thomas A, TIPPIN, Timothy K, YEAGER, Russell L, BATCHELOR, Kenneth W
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Science 01.10.2001
Subjects
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Urinary system
Finasteride
Prostate disease
Rat
Enzyme
Isozyme
Hyperplasia
Rodentia
Oral administration
Enzyme inhibitor
Antiandrogen
Urogenital system diseases
Antihormone
Azasteroid
Prevention
Testosterone
Vertebrata
Mammalia
Animal
Oxidoreductases
Sex steroid hormone
Mechanism of action
Pharmacokinetics
3-Oxo-5α-steroid 4-dehydrogenase
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ISSN:0006-2952
1873-2968
DOI:10.1016/S0006-2952(01)00728-6