Molecular analysis of Hodgkin's disease with abundant Reed-Sternberg cells

The pathogenesis of Hodgkin's disease (HD) has been elusive largely because of the paucity of the Reed-Sternberg cells in comparison to large numbers of normal inflammatory cells in biopsy specimens. This report attempts to characterize Hodgkin's disease by studying subtypes with a high pr...

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Bibliographic Details
Published inHematologic pathology Vol. 4; no. 1; p. 27
Main Authors Hu, E H, Ellison, D, Zovich, D, Nichols, P, Pattengale, P
Format Journal Article
LanguageEnglish
Published United States 1990
Subjects
Cell Count - methods
Cloning, Molecular
Gene Rearrangement - immunology
Hodgkin Disease - genetics
Hodgkin Disease - immunology
Hodgkin Disease - pathology
Humans
Phenotype
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Summary:The pathogenesis of Hodgkin's disease (HD) has been elusive largely because of the paucity of the Reed-Sternberg cells in comparison to large numbers of normal inflammatory cells in biopsy specimens. This report attempts to characterize Hodgkin's disease by studying subtypes with a high proportion of Reed-Sternberg cells and their variants. We found in 4 out of 6 cases, clonal heavy and light chain immunoglobulin (Ig) gene rearrangements. The Ig rearrangement results are compared with the proportion of RS cells seen in the biopsy specimens and the data are correlated with the current literature.
ISSN:0886-0238