Human DNA topoisomerase II: biochemistry and role in chemotherapy resistance (review)

Recently, it has been discovered that DNA topoisomerases are the target of many anti-cancer drugs which were already widely used in the clinic. Using the latest molecular biological techniques much has been learned about the function of DNA topoisomerases in normal cells and in cancer cells, and abo...

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Bibliographic Details
Published inAnticancer research Vol. 16; no. 4A; p. 1867
Main Authors Withoff, S, De Jong, S, De Vries, E G, Mulder, N H
Format Journal Article
LanguageEnglish
Published Greece 01.07.1996
Subjects
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
DNA Topoisomerases, Type II - chemistry
DNA Topoisomerases, Type II - genetics
DNA Topoisomerases, Type II - metabolism
Drug Resistance, Neoplasm
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
Gene Expression Regulation, Enzymologic
Humans
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - genetics
Point Mutation
Promoter Regions, Genetic
Protein Folding
Sequence Deletion
Transcription, Genetic
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Summary:Recently, it has been discovered that DNA topoisomerases are the target of many anti-cancer drugs which were already widely used in the clinic. Using the latest molecular biological techniques much has been learned about the function of DNA topoisomerases in normal cells and in cancer cells, and about how anticancer drugs inhibit these enzymes. In this review we present an overview of the function of human type II DNA topoisomerases, how they are inhibited by certain drugs and on how cancer cells may become resistant to these drugs.
ISSN:0250-7005