Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review

Remdesivir has seen extensive use during the coronavirus disease-2019 pandemic given its clinically proven efficacy against severe acute respiratory syndrome coronavirus type 2. There has been little cited regarding adverse effects. Here we present the case of a patient with marked sinus bradycardia...

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Published inJACC. Case reports Vol. 2; no. 14; pp. 2260 - 2264
Main Authors Gubitosa, James C, Kakar, Parul, Gerula, Christine, Nossa, Hernando, Finkel, Diana, Wong, Kristin, Khatri, Megna, Ali, Hasan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 18.11.2020
Subjects
Case Report
cardiovascular disease
h-mtRNAP, human mitochondrial RNA polymerase
physical examination
AV, atrioventricular
electrocardiogram
electrophysiology
shortness of breath
chest pain
COVID-19, coronavirus disease-2019
LBBB, left bundle branch block
ECG, electrocardiogram
cancer
bradycardia
lethargy
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Summary:Remdesivir has seen extensive use during the coronavirus disease-2019 pandemic given its clinically proven efficacy against severe acute respiratory syndrome coronavirus type 2. There has been little cited regarding adverse effects. Here we present the case of a patient with marked sinus bradycardia that began acutely on initiation of remdesivir and resolved almost immediately on cessation of the drug. ( ).
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:2666-0849
2666-0849
DOI:10.1016/j.jaccas.2020.08.025