Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part I: Preliminary studies of bone parameters

Ukrain, thiophosphoric acid alkaloid derivatives from Chelidonium majus L. was administered intraperitoneally in a dose of 28 mg/kg (equivalent to 0.1 LD50) every other day for six months to female rats with ovariectomy-induced early osteoporosis. Administration of Ukrain was started on the second d...

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Published inDrugs under experimental and clinical research Vol. 22; no. 3-5; p. 173
Main Authors Jagiełło-Wojtowicz, E, Kleinrok, Z, Nowicky, J W, Jabłonski, M, Gorzelak, M, Chodkowska, A, Feldo, M, Matuszek, B
Format Journal Article
LanguageEnglish
Published Switzerland 1996
Subjects
Alkaloids - pharmacology
Animals
Antineoplastic Agents - pharmacology
Berberine Alkaloids
Body Weight - drug effects
Bone and Bones - drug effects
Drug Administration Schedule
Female
Osteoporosis - drug therapy
Osteoporosis - etiology
Ovariectomy - adverse effects
Phenanthridines
Rats
Rats, Wistar
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Summary:Ukrain, thiophosphoric acid alkaloid derivatives from Chelidonium majus L. was administered intraperitoneally in a dose of 28 mg/kg (equivalent to 0.1 LD50) every other day for six months to female rats with ovariectomy-induced early osteoporosis. Administration of Ukrain was started on the second day after the surgical operation. At the end of the long-term treatment with Ukrain each rat was tested for the strength of both humeri and some parameters of rat femur were measured. The body weight of ovariectomized rats was also examined. The present results show that the decrease in the mechanical strength of the humeral bones and some changes in the femur caused by ovariectomy were prevented by the six-month treatment with Ukrain. However, in both ovariectomized groups and in ovariectomized rats pretreated with Ukrain an increase of body weight was observed.
ISSN:0378-6501