Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain

Quantitative in situ hybridization analysis of catalytic (trkB TK+) and non-catalytic (trkB TK-) trkB mRNAs in the postnatal rat brain demonstrated regional differences in expression and revealed transient increases in trkB TK+ expression. Hybridization of trkB TK+ mRNA was observed in thalamic nucl...

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Bibliographic Details
Published inNeuroreport Vol. 4; no. 9; p. 1091
Main Authors Dugich-Djordjevic, M M, Ohsawa, F, Hefti, F
Format Journal Article
LanguageEnglish
Published England 01.09.1993
Subjects
Animals
Brain - anatomy & histology
Brain - growth & development
Brain Chemistry - physiology
Female
Hippocampus - growth & development
Hippocampus - metabolism
In Situ Hybridization
Nerve Growth Factors - biosynthesis
Nerve Tissue Proteins - biosynthesis
Neurotrophin 3
Pregnancy
Rats
Rats, Sprague-Dawley
Receptor Protein-Tyrosine Kinases - biosynthesis
RNA Probes
RNA, Messenger - biosynthesis
Sulfur Radioisotopes
Thalamic Nuclei - growth & development
Thalamic Nuclei - metabolism
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Summary:Quantitative in situ hybridization analysis of catalytic (trkB TK+) and non-catalytic (trkB TK-) trkB mRNAs in the postnatal rat brain demonstrated regional differences in expression and revealed transient increases in trkB TK+ expression. Hybridization of trkB TK+ mRNA was observed in thalamic nuclei between P4 and P8, but not in the adult. In hippocampal structures, transient elevations of trkB TK+ mRNA were apparent between P13 and P17. In contrast, there was a gradual developmental increase in trkB TK- mRNA expression in the hippocampus.
ISSN:0959-4965