Factors for predicting successful immune response to hepatitis b vaccination in HIV-1 infected patients

• Published in: Southeast Asian journal of tropical medicine and public health Vol. 38; no. 4; pp. 680 - 685
• Main Authors: UNGULKRAIWIT, Prayut, JONGJIRAWISAN, Yongyuth, ATAMASIRIKUL, Kalayanee, SUNGKANUPARPH, Somnuek
• Format: Journal Article
• Language: English
• Published: Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01.07.2007; Central Coordinating Board, SEAMEO-TROPMED Project
• Subjects: Adult; Biological and medical sciences; CD4 Lymphocyte Count; Female; Forecasting; General aspects; Hepatitis B; Hepatitis B - prevention & control; Hepatitis B Antibodies - blood; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; HIV Infections - immunology; HIV-1 - immunology; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Prospective Studies; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Immunopathology; Immune response; Vaccination; Hepatic disease; AIDS; Immune deficiency; Infection; Viral hepatitis B; Prevention; Immunoprophylaxis; Viral disease; Digestive diseases; Tropical medicine
• ISSN: 0125-1562

This study aimed to determine the predicting factors for successful hepatitis B vaccination among HIV-1 infected patients. A prospective study was conducted among HIV-1 infected patients who had negative HBV serologies. Anti-HBs antibody was evaluated one month after completing a 3-injection course of hepatitis B vaccine. Patients who had an anti-HBs antibody level >10 mlU/ml were defined as responders. There were 65 patients with a mean age of 39+/-8.5 years, 68% were females. Fifty-seven (88%) patients had received antiretroviral therapy for a mean (SD) duration of 26.1 (22.3) months and 75% of these had an HIV-1 RNA count <50 copies/ml. The mean (SD) CD4 cell count and percentage at the time of vaccination were 345 (194) cells/mm3 and 16 (7) %, respectively. Thirty patients (46%) were responders. Compared to non-responders, responders had a higher mean CD4 cell count (p = 0.047) and a trend toward a younger age (p = 0.052). On multivariate analysis, younger age (p = 0.049) and higher CD4 cell count (p = 0.048) were predictors for successful response to hepatitis B vaccination. Determination of antibody levels after vaccination in HIV-infected patients is warranted.