Side effects of omeprazole: a system biology study

• Published in: Gastroenterology and hepatology from bed to bench Vol. 14; no. 4; pp. 334 - 341
• Main Authors: Hamzeloo-Moghadam, Maryam, Rezaei Tavirani, Mostafa, Jahani-Sherafat, Somayeh, Rezaei Tavirani, Sina, Esmaeili, Somayeh, Ansari, Mojtaba, Ahmadzadeh, Alireza
• Format: Journal Article
• Language: English
• Published: Iran Shaheed Beheshti University of Medical Sciences 01.01.2021
• Subjects: Original; Omeprazole; System biology; Network analysis
• ISSN: 2008-2258; 2008-4234
• DOI: 10.22037/ghfbb.v14i4.2179

To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.