Does treatment guided by vitamin K in the diet alter the quality of life of anticoagulated patients?

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 27; no. 4; pp. 1328 - 1333
• Main Authors: Silva de Assis, M C, Nascimento Cruz, L, Zuchinali, P, Rohde, L E, Rejane Rabelo, E
• Format: Journal Article
• Language: English; Portuguese
• Published: Spain Grupo Arán 01.07.2012
• Subjects: Adult; Aged; Anticoagulants - therapeutic use; Brazil; Diet; Female; Humans; International Normalized Ratio; Male; Middle Aged; Nutrition & Dietetics; Outpatients; Patient Satisfaction; Quality of Life; Vitamin K - administration & dosage; Brazil; Anticoagulants; Dieta; Calidad de Vida; Diet; Clinical Trial; Ensayo Clínico; Vitamina K; Anticoagulantes; Quality of Life; Vitamin K
• ISSN: 1699-5198; 1699-5198
• DOI: 10.3305/nh.2012.27.4.5847

To compare whether health-related quality of life (HRQoL) is altered in patients undergoing a treatment strategy guided by changes in dietary vitamin K. This study is a randomized clinical trial carried out with chronic oral anticoagulation outpatients randomized into a control group (conventional dose adjustment of oral anticoagulants) (n = 66) and an intervention group (strategy based on changes in dietary vitamin K intake) (n = 66). HRQoL was measured using the Duke Anticoagulation Satisfaction Scale (DASS) at baseline and 90 days of follow-up. Patients with worse HRQoL were younger (p = 0.005) and were using a higher dose of baseline oral anticoagulants (p = 0.008), while those with better HRQoL scores had a higher level of education (p = 0.01). Both groups had significant improvements in HRQoL from baseline to 90 days in the global DASS score (p < 0.001), as well as in the negative and positive psychological impact (p < 0.001) domains. We did not observe differences in the variations of HRQoL scores in any of the DASS domains (p values > 0.05) between groups of interventions. Patients who achieved oral anticoagulation stability (n = 23) had significantly better HRQoL scores than patients who did not achieve stability (p = 0.003). Patients receiving the treatment strategy based on changes in dietary vitamin K intake did not have better HRQoL scores; however, both treatment approaches to manage oral anticoagulation improved HRQoL. Patients with greater oral anticoagulation stability had better HRQoL scores.