The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats

Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects....

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Published inNeuroscience and behavioral physiology Vol. 32; no. 2; pp. 189 - 194
Main Authors Danilova, R A, Rud'ko, O I, Korotkova, T M, Obukhova, M F, Ashmarin, I P
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.03.2002
Subjects
Alcohol Drinking - immunology
Animals
Anxiety
Anxiety - immunology
Anxiety - physiopathology
Behavior
Behavior, Animal - physiology
Cognition & reasoning
Conditioning, Operant - drug effects
Depression - psychology
Experiments
Exploratory Behavior - physiology
Fear - physiology
Immunization
Immunoenzyme Techniques
Male
Memory
Motor Activity - physiology
Pain Measurement - drug effects
Peptide Fragments - immunology
Peptides
Physiology
Rats
Rats, Wistar
Swimming - psychology
Tetragastrin - immunology
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Summary:Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.
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ISSN:0097-0549
1573-899X
DOI:10.1023/A:1013983626780