Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation

This review summarizes recent advances in our understanding of neuronal T-type calcium channel regulation as well as their physiological and pathophysiological roles. Through their ability to conduct calcium across the cellular membrane at potentials close to the resting potential, T-type calcium ch...

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Bibliographic Details
Published inJournal of medicine and life Vol. 4; no. 2; pp. 126 - 138
Main Author Iftinca, M C
Format Journal Article
LanguageEnglish
Published Romania Carol Davila University Press 15.05.2011
Subjects
Animals
Calcium Channels, T-Type - metabolism
Humans
Neurons - metabolism
Review
T–type
calcium channel
epilepsy
sleep
pain
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Summary:This review summarizes recent advances in our understanding of neuronal T-type calcium channel regulation as well as their physiological and pathophysiological roles. Through their ability to conduct calcium across the cellular membrane at potentials close to the resting potential, T-type calcium channels are critically important for regulating neuronal excitability, both in the central and peripheral nervous system. T-type channels are also linked to an increasing number of neurological disorders such as the absence epilepsy and neuropathic pain. Although there is substantial literature dealing with regulation of native T-type channels, the underlying molecular mechanism has only recently been addressed. It is, therefore, critical to understand the cellular mechanisms that control T-type channel activity and expression, because this could provide important insight into designing novel therapeutic strategies targeting these channels.
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ISSN:1844-122X
1844-3117