Insect cell-expressed p180(erbB3) possesses an impaired tyrosine kinase activity

Results of a study show that although p180erbB3, a receptor tyrosine kinase, is capable of binding ATP and heregulin, its catalytic activity is at least 2 orders of magnitude less than that of the epidermal growth factor receptor. It is proposed that p180erbB3 has an impaired intrinsic tyrosine kina...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 91; no. 17; p. 8132
Main Authors Guy, Pamela M, Platko, Jill V, Cantley, Lewis C, Cerione, Richard A, Carraway, Kermit L
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 16.08.1994
Subjects
Amino acids
Biochemistry
Enzymes
Insects
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Summary:Results of a study show that although p180erbB3, a receptor tyrosine kinase, is capable of binding ATP and heregulin, its catalytic activity is at least 2 orders of magnitude less than that of the epidermal growth factor receptor. It is proposed that p180erbB3 has an impaired intrinsic tyrosine kinase activity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.17.8132