Diagnostic approach of pheochromocytomas and paragangliomas

Pheochromocytomas and paragangliomas are rare neuroendocrine tumours associated with high morbidity and mortality. Recognizing the clinical presentation is the first step for diagnosis. Biochemical studies may determine an excess of catecholamines and their metabolites. However, the available tests...

Full description

Saved in:
Bibliographic Details
Published inHipertension y riesgo vascular Vol. 36; no. 1; p. 34
Main Authors Gómez, R M, Hernaiz, M, de Miguel, V, Aparicio, L S, Marín, M J, Lupi, S, Barontini, M
Format Journal Article
LanguageSpanish
Published Spain 01.01.2019
Subjects
Adrenal Gland Neoplasms - diagnosis
Adrenal Gland Neoplasms - genetics
Adrenal Gland Neoplasms - pathology
Germ-Line Mutation
Humans
Magnetic Resonance Imaging - methods
Paraganglioma - diagnosis
Paraganglioma - genetics
Paraganglioma - pathology
Pheochromocytoma - diagnosis
Pheochromocytoma - genetics
Pheochromocytoma - pathology
Tomography, X-Ray Computed - methods
Catecolaminas
Pheochromocytoma
Feocromocitomas
Paraganglioma
Catecholamines
Adrenal gland
Glándula suprarrenal
Online AccessGet more information

Cover

More Information
Summary:Pheochromocytomas and paragangliomas are rare neuroendocrine tumours associated with high morbidity and mortality. Recognizing the clinical presentation is the first step for diagnosis. Biochemical studies may determine an excess of catecholamines and their metabolites. However, the available tests offer varying diagnosis precision. Computed tomography and magnetic resonance are highly sensitive for locating these tumours. Functional tests are reserved for when metastatic and multifocal disease are suspected. One third of the patients have a germline mutation and many genes are involved in the development of these tumours.
ISSN:1989-4805
DOI:10.1016/j.hipert.2018.06.003