Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo

The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis. Twenty patients with non-segmental vitiligo (NSV) were...

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Published inGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia Vol. 151; no. 5; p. 473
Main Authors Elgarhy, Lamia H, Abdullatif, Amani, Abdelazim, Rehab, El-Desouky, Karima I
Format Journal Article
LanguageEnglish
Published Italy 01.10.2016
Subjects
Adolescent
Adult
Biopsy - methods
Case-Control Studies
Cell Adhesion - genetics
Discoidin Domain Receptor 1 - genetics
Female
Humans
Immunohistochemistry
Male
Melanocytes - metabolism
Middle Aged
Vitiligo - genetics
Vitiligo - pathology
Young Adult
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Summary:The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis. Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression. Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found. Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.
ISSN:1827-1820