A novel screening test for esophageal squamous cell carcinoma: sirtuin-3

Human sirtuin-3, a protein involved in the mediation of tumors, has been shown to be present in malignancies. The goal of this study was to measure serum sirtuin-3 levels in esophageal squamous cancer cells and to determine whether sirtuin-3 may possess predictive value in advanced cases of esophage...

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Bibliographic Details
Published inEuropean review for medical and pharmacological sciences Vol. 21; no. 23; p. 5399
Main Authors Cobanoğlu, U, Dülger, C, Kemik, O, Celik, S, Sayir, F
Format Journal Article
LanguageEnglish
Published Italy 01.12.2017
Subjects
Adult
Aged
Biomarkers, Tumor - blood
Carcinoma, Squamous Cell - diagnosis
Early Detection of Cancer
Enzyme-Linked Immunosorbent Assay
Esophageal Neoplasms - diagnosis
Esophageal Squamous Cell Carcinoma
Female
Humans
Male
Middle Aged
Sirtuin 3 - blood
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Summary:Human sirtuin-3, a protein involved in the mediation of tumors, has been shown to be present in malignancies. The goal of this study was to measure serum sirtuin-3 levels in esophageal squamous cancer cells and to determine whether sirtuin-3 may possess predictive value in advanced cases of esophageal squamous cell carcinoma (ESCC). A total of 130 ESCC patients and 50 healthy control subjects participated to the study. Serum sirtuin-3 levels for all 180 subjects were measured using enzyme-linked immunosorbent assay (ELISA). Median sirtuin-3 levels were significantly higher in patients with ESCC than in the control subjects. The presence of considerably elevated levels of sirtuin-3, could be a powerful mediator of advanced ESCC in ESCC patients, suggests that sirtuin-3 may be a useful indicator of the disease.
ISSN:2284-0729