Effect of venlafaxine and nicotine on the level of neurotransmitters and their metabolites in rat brains

Nicotine (NIC) and venlafaxine (VEN) have been proved to exert antidepressant activity in both human and animals. The effect of antidepressant doses of NIC and VEN (our previous results) on noradrenergic (NA), dopaminergic (DA), serotoninergic (5-HT) neurotransmitters and their metabolites: DOPAC, H...

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Published inJournal of physiology and pharmacology : an official journal of the Polish Physiological Society Vol. 61; no. 3; p. 339
Main Authors Czubak, A, Nowakowska, E, Golembiowska, K, Kus, K, Burda, K, Metelska, J
Format Journal Article
LanguageEnglish
Published Poland 01.06.2010
Subjects
3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Antidepressive Agents, Second-Generation - pharmacology
Cyclohexanols - pharmacology
Dopamine - metabolism
Female
Ganglionic Stimulants - pharmacology
Hippocampus - drug effects
Hippocampus - metabolism
Homovanillic Acid - metabolism
Hydroxyindoleacetic Acid - metabolism
Microdialysis
Neurotransmitter Agents - metabolism
Nicotine - pharmacology
Norepinephrine - metabolism
Rats
Rats, Wistar
Serotonin - metabolism
Venlafaxine Hydrochloride
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Summary:Nicotine (NIC) and venlafaxine (VEN) have been proved to exert antidepressant activity in both human and animals. The effect of antidepressant doses of NIC and VEN (our previous results) on noradrenergic (NA), dopaminergic (DA), serotoninergic (5-HT) neurotransmitters and their metabolites: DOPAC, HVA and 5-HIAA in rats' hippocampus in freely moving rats were determined by microdialysis technique and HPLC method. Both drugs release 5-HT and NA, but VEN to a greater degree. DA level was affected only by VEN, however NIC extended the response of the DA system on VEN's effect. Combined administration of drugs caused the greatest changes in the 5-HT system. Both drugs contributed to reduction in neurotransmitter biotransformation.
ISSN:1899-1505