Miniaturization of enantioselective detectors

Combinations of polarimetry, circular dichroism, and LC are replacing UV for effective detection and isolation of enantiomers. Because of the virtually identical physical properties of two enantiomers in a pair, conventional analytical approaches do not work. However, the determination of enantiomer...

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Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 73; no. 17; pp. 488A - 496A
Main Authors EDKINS, Thomas J, BOBBITT, Donald R
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.09.2001
Subjects
Algorithms
Analytical chemistry
Atoms & subatomic particles
Chemistry
Chromatographic methods and physical methods associated with chromatography
Circular Dichroism
Exact sciences and technology
Other chromatographic methods
Pharmaceutical industry
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - isolation & purification
Sensors
Spectrophotometry, Ultraviolet
Stereoisomerism
Separation method
Analysis method
Enantioselectivity
Coupled method
Circular dichroism spectrometry
Charge coupled device
Chiral stationary phase
Liquid chromatography
Polarimetry
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Summary:Combinations of polarimetry, circular dichroism, and LC are replacing UV for effective detection and isolation of enantiomers. Because of the virtually identical physical properties of two enantiomers in a pair, conventional analytical approaches do not work. However, the determination of enantiomeric purity is an extremely challenging and highly important procedure driven by USFDA regulations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0003-2700
1520-6882